STEP 1
Sterile Lyophilization
Compounds are produced under documented quality procedures, then freeze-dried and nitrogen-sealed in sterile vials.
CJC-1295 no DAC
CAS #: 863288-34-0
Research Use Only
Peptide Portal supplies research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Products are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration.
CJC-1295 no DAC Overview
CJC-1295 No DAC is a modified GHRH(1-29) analog incorporating four amino acid substitutions at positions 2, 8, 15, and 27 designed to confer resistance to dipeptidyl peptidase-4 (DPP-4) degradation while preserving receptor binding affinity. Unlike the DAC-modified version with extended half-life, this variant maintains a shorter duration of action (approximately 30 minutes), enabling amplification of physiologic GH pulse patterns rather than sustained elevation. Research models examine its effects on pituitary GHRH receptor activation, growth hormone secretagogue activity, IGF-1 pathway stimulation, circadian GH rhythm modulation, and metabolic signaling in laboratory settings. Teichman et al. (2006). Alba et al. (2005)
History
CJC-1295 was developed by ConjuChem Biotechnologies in the early 2000s as part of efforts to create GHRH analogs with improved pharmacokinetic properties. The original CJC-1295 with DAC (drug affinity complex) was designed for prolonged activity through albumin binding, reaching phase II experimental programs before discontinuation. The No DAC variant, retaining the core GHRH(1-29) modifications without the albumin-binding complex, emerged as a research tool for studying pulsatile signaling dynamics and has become widely utilized in somatotroph axis investigations.
Teichman et al. (2006).
CJC-1295 no DAC Structure
- CAS #:
- 863288-34-0
- Molecular Formula:
- C₁₆₅H₂₆₉N₄₇O₄₆
- Molecular Weight:
- 3647.28 g/mol
- PubChem ID:
- 91976529
STEP 2
Independent Verification
ISO 17025 accredited third-party labs verify every lot — purity by HPLC, identity by mass spectrometry.
STEP 3
Rapid Dispatch
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Each vial contains the labelled quantity of lyophilized peptide. The stated milligram figure refers to the peptide content, not the total mass of the lyophilized cake.
Reconstitution requires bacteriostatic water and appropriate laboratory equipment, which are not included.
Products ship as research materials without directions for use. Handling should follow your own laboratory protocols.
Store lyophilized material at 2-8°C and away from light. Once reconstituted, follow your laboratory's stability guidance.
